Single-Cell Study Offers New Clue into Causes of Cystic Fibrosis

Single-Cell Study Offers New Clue into Causes of Cystic Fibrosis

Single-Cell Study Offers New Clue into Causes of Cystic FibrosisPosted on May 27th, 2021 by Dr. Francis CollinsCredit: Carraro G, Nature, 2021More than 30 years ago, I co-led the Michigan-Toronto team that discovered that cystic fibrosis (CF) is caused by an inherited misspelling in the cystic fibrosis transmembrane conductance regulator (CFTR) gene [1]. Running closely alongside it is a layer of basal cells (outlined in red), which includes stem cells that are essential for repairing and regenerating upper airway tissue. These findings come from a team led by Kathrin Plath and Brigitte Gomperts, University of California, Los Angeles; John Mahoney, Cystic Fibrosis Foundation, Lexington, MA; and Barry Stripp, Cedars-Sinai, Los Angeles. References:[1] Identification of the cystic fibrosis gene: chromosome walking and jumping. [2] Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.

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