Nanoparticle Technology Holds Promise for Protecting Against Many Coronavirus Strains at Once

Nanoparticle Technology Holds Promise for Protecting Against Many Coronavirus Strains at Once

Nanoparticle Technology Holds Promise for Protecting Against Many Coronavirus Strains at OncePosted on January 26th, 2021 by Dr. Francis CollinsA new coronavirus vaccine approach works by attaching many spike protein receptor-binding domains (RBDs) to an engineered protein-based nanoparticle. In mice, the vaccine induced a cross-reactive antibody response capable of neutralizing many different coronavirus strains. This new work, published in the journal Science, utilizes a technology called a mosaic nanoparticle vaccine platform [1]. When mixed with the nanoparticle, the spike protein fragments stuck to the cage, resulting in a vaccine nanoparticle with spikes representing four to eight distinct coronavirus strains on its surface. The findings raise the exciting possibility that this new vaccine technology could provide protection against many coronavirus strains with a single shot.

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