Muscle Enzyme Explains Weight Gain in Middle Age

Muscle Enzyme Explains Weight Gain in Middle Age

Muscle Enzyme Explains Weight Gain in Middle AgePosted on May 9th, 2017 by Dr. Francis CollinsThe struggle to maintain a healthy weight is a lifelong challenge for many of us. An NIH-led team recently discovered that the normal process of aging causes levels of an enzyme called DNA-PK to rise in animals as they approach middle age. To see if reducing DNA-PK levels might rev up the metabolism, the researchers turned to middle-aged mice. They found that a drug-like compound that blocked DNA-PK activity cut weight gain in the mice by a whopping 40 percent! The researchers suspected that an increase in DNA-PK in middle age might lead directly to weight gain.

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