Mapping Severe COVID-19 in the Lungs at Single-Cell ResolutionPosted on April 13th, 2021 by Dr. Francis CollinsCaption: Image shows macrophages (red), fibroblast cells (green), and other cells (blue). As shown above, a team of NIH-funded researchers has done just that, capturing changes in the lungs over the course of a COVID-19 infection at unprecedented, single-cell resolution. What was missing was an understanding of the precise interplay between immune cells and lung tissue infected with SARS-CoV-2. The results showed that macrophages are much more abundant in the lungs of severe COVID-19 patients compared to other lung infections. In late COVID-19, macrophages also increase in the walls of alveoli, where they interact with lung cells known as fibroblasts.
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