Human Antibodies Target Many Parts of Coronavirus Spike ProteinPosted on May 18th, 2021 by Dr. Francis CollinsCaption: People who recovered from mild COVID-19 infections produced antibodies circulating in their blood that target three different parts of the coronavirus’s spike protein (gray). This picture suggests that an effective neutralizing immune response targets a wider swath of the virus’ now-infamous spike protein than previously recognized. Rather than narrowing the search, Ippolito, Lavinder, and colleagues analyzed the complete repertoire of antibodies against the spike protein from four people soon after their recoveries from mild COVID-19. What the researchers found was a bit of a surprise: the vast majority of antibodies—about 84 percent—targeted other portions of the spike protein than the RBD. Also noteworthy, about 40 percent of the circulating antibodies target yet another portion of the spike called the S2 subunit.
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