How Severe COVID-19 Can Tragically Lead to Lung Failure and DeathPosted on May 11th, 2021 by Dr. Francis CollinsMore than 3 million people around the world, now tragically including thousands every day in India, have lost their lives to severe COVID-19. He and his team performed single-cell RNA sequencing on about 116,000 cells from the lung tissue of 19 men and women. While macrophages normally help to fight an infectious virus, they seemed in this case to produce a vicious cycle of severe inflammation that further damaged lung tissue. But in severe COVID-19, both studies suggest this isn’t always possible. Links:COVID-19 Research (NIH)Izar Lab (Columbia University, New York)Aviv Regev (Genentech, South San Francisco, CA)NIH Support: National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism
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