Diaper Compound Brings Change to Cell MicroscopyPosted on March 26th, 2015 by Dr. Francis CollinsLight microscopy has been a mainstay of neuroscience and many areas of biology for more than a century. The sample is then embedded within a 3D mesh of sodium polyacrylate, with the fluorescent molecules on the antibodies connecting to the sodium polyacrylate. The researchers then add water, and the polymer matrix swells evenly in three dimensions just as it does in a diaper. The final product is a neural landscape with greatly enlarged cell structures that also appear transparent, making them perfect for microscopy. Expansion microscopy can be used to scan whole brain structures and show entire neural networks in 3D.
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