ADAPT-2 Trial Results Deliver a Breakthrough in Long Search for Methamphetamine Use Disorder Medication | National Institute on Drug Abuse

ADAPT-2 Trial Results Deliver a Breakthrough in Long Search for Methamphetamine Use Disorder Medication | National Institute on Drug Abuse

The U.S. is facing a surge of overdose deaths involving the use of stimulant drugs, including cocaine and methamphetamine. As more patients and providers become familiar with the multiple effective medications now available to treat opioids, the lack of any medication to treat addiction to methamphetamine is increasingly frustrating. There were no significant adverse effects of the medication combination, and participants generally adhered to the treatment. Previously, both bupropion and naltrexone had been tried on their own in the treatment of methamphetamine use disorder, with modest but inconsistent results in both cases. Compounds that can mimic the effects of a misused drug but less rapidly and intensely are obvious choices as addiction medication candidates.

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