Making Personalized Blood-Brain Barriers in a Dish

Making Personalized Blood-Brain Barriers in a Dish

Making Personalized Blood-Brain Barriers in a DishPosted on June 27th, 2019 by Dr. Francis CollinsCredit: Vatine et al, Cell Stem Cell, 2019The blood-brain barrier, or BBB, is a dense sheet of cells that surrounds most of the brain’s blood vessels. To help look for solutions to these and other problems, researchers can now grow human blood-brain barriers on a chip like the one pictured above. In close association are supportive brain cells known as astrocytes (green), which help to regulate blood flow. The BBB chips also show electrical resistance and permeability just as would be expected in a person. Reference:[1] Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.

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